Monocyte chemoattractant protein-1 increases glioma aggressiveness in vivo.

2003 NOV 11 - (NewsRx.com & NewsRx.net) -- Monocyte chemoattractant protein-1 increases glioma aggressiveness in an animal model by increasing microglia.

According to a study from Germany, "Macrophages are thought to represent a first line of defense in antitumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are still highly aggressive tumors.

"We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, …